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Date: | Mon, 8 Apr 2013 04:45:28 -0400 |
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The Dartmouth Society for Industrial and Applied Mathematics would like
to invite you to the following session:
Time: Thursday, April 11th 2013 6 - 7:30 pm
Location: Kemeny 004
Speaker: Chris Bailey-Kellogg (Associate Professor in Computer Science
Department at Dartmouth College.)
Seminar Topic: Optimization algorithms for the design of immunotolerant
biotherapies
Pizza will be served.
Abstract: The explosive growth of biotherapeutics is revolutionizing
the treatment of numerous diseases.
However, a therapeutic protein may be seen as non-"self" by the human
immune system, inducing a detrimental response.
Our goal is to develop new variants of a given therapeutic protein that
will evade detection by the immune system while
still maintaining the desired therapeutic function. To do so, we have
developed combinatorial optimization algorithms
that balance the two competing criteria, mapping the Pareto frontier in
order to identify sets of mutations that make
the best trade offs between immunogenicity and function. The talk will
introduce the problem context (no previous
biology background is required), dive into the mathematical
formulations and algorithmic approaches, and discuss the
application of our methods by experimental collaborators.
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